Faculty of Science Mass Spectrometry Centre https://www.sheffield.ac.uk/mass-spectrometry/

The Faculty of Science Mass Spectrometry Centre is run by a group of scientists with a strong background in mass spectrometry combined with specialist knowledge in chemistry, biochemistry, molecular biology and cell biology. In our two facilities, chemMS and biOMICS, our staff have a wealth of experience in sample preparation and method development, complemented by state-of-the-art equipment to provide a wide variety of analytical workflows for elemental analysis, small molecules, metabolites and proteins. We have a large range of equipment including different mass spectrometers and liquid and gas chromatography instrumentation.

For proteomics and metabolomics, we offer a range of hyphenated mass spectrometry techniques (including LC-MS, LC-MS/MS & GC-MS) with a variety of acquisition modes (including targeted, data dependent analysis, data independent analysis) and fragmentation techniques (including CID, HCD, ETD) to analyse very complex biological samples. We have the capability to perform single cell resolution MALDI imaging with ion mobility separation. In chemMS, we can analyse relatively complex mixtures and pure organic compounds with liquid or gas chromatography, direct infusion, Atmospheric Solids Analysis Probe (ASAP) and MALDI coupled to mass spectrometers. Inductively coupled plasma (ICP)-based techniques are utilised to determine elemental ratios and analyse inorganic species.

All enquiries to mark.collins@sheffield.ac.uk